Onychomadesis is characterized by separation of the nail plate from the matrix due to a temporary arrest in nail matrix activity. Hand-foot-and-mouth disease (HFMD) is a relatively common viral infection, especially in children.Click to see full answer. Hereof, can hand foot and mouth disease cause your nails to fall off?Very rarely, people may lose a fingernail or toenail after having hand, foot, and mouth disease. Most reports of fingernail and toenail loss have been in children. In these reported cases, the person usually lost the nail within a few weeks after being sick. The nail usually grew back on its own.Also Know, what are the after effects of hand foot and mouth disease? The most common complication of hand-foot-and-mouth disease is dehydration. The illness can cause sores in the mouth and throat, making swallowing painful and difficult. Hand-foot-and-mouth disease is usually a minor illness causing only a few days of fever and relatively mild signs and symptoms. Also question is, how long after hand foot and mouth do nails fall off? The spots and blisters usually go away after about 7 to 10 days. Peeling skin and loss of fingernails or toenails have also been reported, mostly in children, within weeks of having hand, foot and mouth disease.How do you clean your house after hand foot and mouth?Wipe down all surfaces that the infected child comes into contact with using disinfecting wipes or cleansers that contain greater than 60% alcohol. Be sure to regularly wash your hands thoroughly with soap and warm water. If soap and water are not available, use a hand sanitizer that contains greater than 60% alcohol.