Toxic granulation is manifested by the presence of large granules in the cytoplasm of segmented and band neutrophils in the peripheral blood. Infection is the most frequent cause of toxic granulation. This phenomenon may be seen in cells which also contain Döhle bodies and/or vacuoles.Click to see full answer. Also asked, what do toxic neutrophils indicate?Toxic neutrophils exhibit a variety of nuclear and cytoplasmic abnormalities in Romanowsky-stained blood smears, and are associated with inflammation and infection.One may also ask, why do neutrophils increase in bacterial infections? Causes. Neutrophils are the primary white blood cells that respond to a bacterial infection, so the most common cause of neutrophilia is a bacterial infection, especially pyogenic infections. Neutrophils are also increased in any acute inflammation, so will be raised after a heart attack, other infarct or burns. Similarly one may ask, what does toxic granulation indicate? Toxic granulation is the term used to describe an increase in staining density and possibly number of granules that occurs regularly with bacterial infection and often with other causes of inflammation (Fig. Severe infection. Neutrophils show toxic granulation. Figure 5.76. Photomicrograph of a blood film.What diseases cause high neutrophils? Some specific causes of an increased neutrophil count (neutrophilia) include: Infections. Stress10? Blood cell-related cancers such as leukemia. Autoimmune disorders such as rheumatoid arthritis. Trauma and burns. Smoking11? Pregnancy. Thyroiditis.