Eating Buckeye Nuts Buckeye nuts are actually mildly toxic in their uncooked state, but you can eat them after removing them from their shells and roasting them. In the past, Native Americans would roast, peel, and mash the buckeye nuts into a fairly nutritional paste that they would eat.Click to see full answer. Also know, are Buckeyes poisonous to humans?Consumption. From leaves to bark, the buckeye tree is a poisonous plant. If not prepared properly though, buckeye nuts are toxic to humans, causing symptoms including: weakness, diarrhea, vomiting, paralysis and death.Additionally, can a Buckeye kill you? Buckeyes are poisonous to people. The nuts and the foliage of the Ohio Buckeye tree, Aesculus glabra, will kill you. Buckeyes will break your teeth before they kill you. If you’ve ever handled a buckeye necklace, you know that buckeyes are super hard. Considering this, what are Buckeyes good for? Though poisonous because of its tannic acid content, the buckeye–at times in history–has been used as a sedative, for relieving constipation and asthma and for the treatment of hemorrhoids and “female disorders.” It is also said to relieve the pain of arthritis and rheumatism.Are Buckeyes poisonous to touch?Any part of the plant, if ingested, is poisonous but just touching it is not harmful. Farmers have been known to remove the buckeye tree from fields where cattle graze to prevent the animals from eating any part of the tree. It can cause paralysis, vomiting, diarrhea, stupor.